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RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it

BD Gelb, M Tartaglia, C Boshoff... - The Journal of ..., 2011 - Am Soc Clin Investig In this issue of the JCI, Wu et al. and Marin et al. describe two new mouse models of inherited disorders of the RAS/MAPK signal transduction pathway that display hypertrophic cardiomyopathy (HCM); the model from the former paper was from a gain-of-function Raf1 mutation, and ...

Effects of calorie restriction on cardioprotection and cardiovascular health.

I Ahmet, HJ Tae, R de Cabo... - Journal of molecular ..., 2011 - Multiple health benefits of calorie restriction (CR) and alternate day fasting (ADF) regimens are widely recognized. Experimental data concerning the effects of calorie restriction on cardiac health are more controversial, ranging from evidence that ADF protects heart from ...

Stroke After Coronary Artery Bypass Graft Surgery—Reply

JF Sabik... - JAMA: The Journal of the American ..., 2011 - Am Med Assoc In Reply: As Dr Fan and colleagues discuss, and we stated as a limitation of our study, we did not report whether the perioperative strokes were due to embolism, thrombosis, hemorrhage, or hypoperfusion. These data are not routinely captured in our prospective ...

A Comparison of Long-Term Mortality for Off-Pump and On-Pump Coronary Artery Bypass Graft Surgery

C Wu, FT Camacho, AT Culliford... - ... Quality and Outcomes, 2012 - Am Heart Assoc Background The survival difference between off-pump and on-pump coronary artery bypass graft surgery for follow-up longer than 5 years is not well-understood. The objective of this study is to examine the difference in 7-year mortality after these 2 procedures.

A patient with angina at night: core curriculum chapters 3 (non-invasive imaging) and 9 (chronic ischaemic heart disease)

FA Flachskampf... - European Heart Journal, 2012 - Eur Soc Cardiology1. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation ...
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