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Changes in left and right ventricular function of donor hearts during the first year after heart transplantation

S Goland, RJ Siegel, K Burton, MA De Robertis... - Heart, 2011 - Objective Expected values of tissue Doppler imaging (TDI) velocities and myocardial performance index (MPI) after heart transplantation (HTx) have not been evaluated. This study assessed left and right ventricular (LV and RV) structure and function during the first ...

IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis

T Yamashita, T Iwakura... - Cardiovascular ..., 2011 - Aims Interleukin (IL)-17-producing helper T (Th17) cells have been proposed to participate in the pathogenesis of chronic inflammation, such as autoimmune myocarditis. IL-6 gene ablation confers the resistance to experimental autoimmune myocarditis (EAM). In this ...

RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it

BD Gelb, M Tartaglia - The Journal of clinical investigation, 2011 - Am Soc Clin Investig In this issue of the JCI, Wu et al. and Marin et al. describe two new mouse models of inherited disorders of the RAS/MAPK signal transduction pathway that display hypertrophic cardiomyopathy (HCM); the model from the former paper was from a gain-of-function Raf1 ...

A Genetic Risk Score is Associated with Incident Cardiovascular Disease and Coronary Artery Calcium-The Framingham Heart Study

G Thanassoulis, GM Peloso, MJ Pencina... - Circulation: ..., 2012 - Am Heart Assoc Page 1. - 1 - A Genetic Risk Score is Associated with Incident Cardiovascular Disease and Coronary Artery Calcium - The Framingham Heart Study Running title: Thanassoulis et al.; Genetic Risk Score and Cardiovascular Disease ...

Myocardial 123I‐metaiodobenzylguanidine Washout and Heart Rate Variability in Asymptomatic Subjects

S Simula, E Vanninen, A Hedman... - Annals of ..., 2012 - Wiley Online Library Background: Myocardial 123 I-metaiodobenzylguanidine (MIBG) kinetics reflect the integrity and function of cardiac presynaptic sympathetic nerve terminals. Heart rate variability (HRV) is an indicator of cardiac sympatho-vagal balance. However, the function of cardiac ...
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