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Sensitive Cardiac Troponin T Assay and the Risk of Incident Cardiovascular Disease in Women With and Without Diabetes Mellitus: The Women's Health Study

BM Everett, NR Cook, MC Magnone, M Bobadilla... - Circulation, 2011 - Am Heart Assoc Methods and Results Using 2 complementary study designs, we evaluated the relationship between baseline cardiac troponin and incident CVD events among diabetic and nondiabetic participants in the Women's Health Study (median follow-up, 12.3 years). All diabetic ...

PON-dering differences in HDL function in coronary artery disease

C Mineo... - The Journal of clinical investigation, 2011 - Am Soc Clin Investig HDL cholesterol activates endothelial cell production of the atheroprotective signaling molecule NO, and it promotes endothelial repair. In this issue of the JCI, Besler et al. provide new data indicating that HDL from stable coronary artery disease (CAD) or acute coronary ...

Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI

Y Zhao, M Pennings, CLJ Vrins, L Calpe-Berdiel... - Atherosclerosis, 2011 - Elsevier High-density lipoprotein (HDL) mediated reverse cholesterol transport (RCT) is regarded to be crucial for prevention of foam cell formation and atherosclerosis. ABC-transporter A1 (ABCA1) and scavenger receptor BI (SR-BI) are involved in the biogenesis of HDL and the ...

Inhibition of PKCα/β With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury

D Ladage, L Tilemann, K Ishikawa... - Circulation ..., 2011 - Am Heart Assoc Rationale: Protein kinase Cα (PKCα) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKCα have enhanced cardiac contractility and ...

Exploring clinical predictors of cardiovascular disease in a central australian aboriginal cohort

JN Luke, AD Brown, L Brazionis... - European Journal of ..., 2012 - Abstract Introduction: For Aboriginal populations, predicting individuals at risk of cardiovascular disease (CVD) is difficult due to limitations and inaccuracy in existing risk-prediction algorithms. We examined conventional and novel risk factors associated with ...
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