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Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy

C Marchesi, R Essalmani, CA Lemari... - Journal of Molecular ..., 2011 - Springer Abstract Proprotein convertase (PC) 5/6 belongs to a family of secretory proteases involved in proprotein proteolysis. Several studies suggest a role for PC5/6 in cardiovascular disease. Because lethality at birth of mice lacking PC5/6 precluded elucidation of its function in the adult, we ...

Diabetes and hypokinetic cardiopathy: when to consider mitochondrial disease?].

C Nozires, V Quillasi, C Mouly-Bertin... - ... de cardiologie et d' ..., 2011 - The association between diabetes mellitus and hypokinetic cardiomyopathy is frequent. We report a case of diabetes and hypokinetic cardiopathy in a 40-year-old man which led to the hypothesis of maternally inherited diabetes and deafness (MIDD) due to a mitochondrial ...

P02-03-Depression and anxiety following open heart surgery: Mediation of coping, spiritual struggle and interleukin-6

A Ai, H Appel... - European Psychiatry, 2011 - Elsevier Objectives Based on multidisciplinary literature and previous findings, our study's objectives are to estimate the parallel psychophysiological pathways from pre-operative distress to post-operative depression in patients undergoing open heart surgery. Aims The study's aims ...

Long-Term Survival in Patients With Resting Obstructive Hypertrophic Cardiomyopathy: Comparison of Conservative Versus Invasive Treatment

W Ball, J Ivanov, H Rakowski, ED Wigle... - Journal of the American ..., 2011 - Elsevier Objectives The aim of this study was to compare the survival of patients with hypertrophic cardiomyopathy (HCM) and resting left ventricular outflow tract (LVOT) obstruction managed with an invasive versus a conservative strategy. Background In patients with resting ... [HTML]

Preoperative Inhalation of Milrinone Attenuates Inflammation in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

M Gong, XZ Lin, GT Lu... - Medical Principles and ..., 2012 - ; i> Objectives:</i> The purpose of this study was to evaluate the effect of preoperative inhalation of milrinone on cardiopulmonary bypass (CPB)-related inflammation.< i> Subjects and Methods:</i> A total of 30 patients undergoing cardiac surgery were recruited and ...
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