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Immunoglobulin treatment ameliorates myocardial injury in experimental autoimmune myocarditis associated with suppression of reactive oxygen species
C Kishimoto, M Nimata, T Okabe... - International Journal of ..., 2012 - Elsevier Aims We tested the hypothesis that immunoglobulin ameliorated experimental autoimmune myocarditis (EAM) in mice attributing to the suppression of reactive oxygen species (ROS)-mediated myocardial injury. Methods We intraperitoneally administered intact type of ...
Fig. 2. IL-1β staining, macrophage infiltration and DHE staining. Intense IL-1β staining (brown areas) and positive macrophage infiltrations (arrows) were shown in the myocardium in untreated (B, inset 380) and F(ab )2 fragments-treated (D) mice with EAM, but not in Ig treated (C) mouse with EAM. In DHE staining, superoxide production was demonstrated by red fluorescence labeling. White arrows indicate the increased DHE stainings. Ig and F(ab )2 fragments suppressed the expressions of DHE compared with the untreated mouse with EAM. Each left panel = IL-1β staining, middle panel = macrophage staining, and right panel = DHE staining. A = normal mouse, B = untreated mouse with EAM, C = Ig-treated mouse with EAM, D = F(ab )2 fragments-treated mouse with EAM. ( 180).
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Immunoglobulin treatment ameliorates myocardial injury in experimental autoimmune myocarditis associated with suppression of reactive oxygen species |
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