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Fulminant myocarditis owing to high-dose interleukin-2 therapy for metastatic melanoma
P Thavendiranathan, D Verhaert... - British Journal of ..., 2011 - Br Inst Radiology High-dose interleukin-2 (IL-2) therapy may cause acute myocarditis characterised by diffuse
myocardial involvement and occasionally fulminant heart failure. Cardiac MRI (CMRI) provides
a comprehensive assessment of myocardial function, inflammation and injury in a single ...
High-dose interleukin-2 (IL-2) therapy may cause acute myocarditis characterised by diffuse myocardial involvement and occasionally fulminant heart failure. Cardiac MRI (CMRI) provides a comprehensive assessment of myocardial function, inflammation and injury in a single examination and has shown value in the diagnosis of myocarditis. We report a case of a 54-year-old male with metastatic melanoma who developed acute severe myocarditis with fulminant heart failure after high-dose IL-2 therapy. CMRI using a combination of T2 weighted imaging and T1 weighted late post-gadolinium enhancement techniques played a key role in establishing the diagnosis. To our knowledge we present the first case report of the combined use of T1 and T2 weighted CMRI techniques to diagnose IL-2 induced myocarditis.
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Fulminant myocarditis owing to high-dose interleukin-2 therapy for metastatic melanoma |
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