Heart Care Info - Heart Disease Prevention & Treatment

Conditional transgenic expression of TIR-domain-containing adaptor-inducing interferon-β (TRIF) in the adult mouse heart is protective in acute viral myocarditis

Z Xu, M Desai, J Philip, N Sivsubramanian... - Basic Research in ..., 2011 - Springer Abstract TIR-domain-containing adaptor-inducing interferon-β (TRIF) plays a major role in Toll-like receptor 3 (TLR3) mediated signaling. Mice deficient in TLR3 and TRIF have been shown to be highly susceptible to enterovirus-induced myocardial injury. These mice have ...