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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

H Schunkert, IR Knig, S Kathiresan, MP Reilly... - Nature genetics, 2011 - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This ...

Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, ...

L Conde, S Bevan, M Sitzer, N Klopp, T Illig... - Atherosclerosis, 2011 - Elsevier Background Recent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT ...

Developmentally Regulated SCN5A Splice Variant Potentiates Dysfunction of a Novel Mutation Associated with Severe Fetal Arrhythmia

LL Murphy, AJ Moon-Grady, BF Cuneo, RT Wakai... - Heart Rhythm, 2011 - Elsevier Background Congenital long-QT syndrome (LQTS) may present during fetal development and can be life-threatening. The molecular mechanism for the unusual early onset of LQTS during fetal development is unknown. Objective We sought to elucidate the molecular ...

Risk stratification in stable coronary artery disease: superiority of N-terminal pro B-type natriuretic peptide over high-sensitivity C-reactive protein, gamma-glutamyl ...

E Bode, T Wuppinger, T Bode, H Alber... - Coronary Artery ..., 2011 - Objective: The aim of the study was to compare N-terminal pro B-type natriuretic peptide (NT-pro BNP), high-sensitivity C-reactive protein, and gamma-glutamyl transferase ([gamma]-GT) with traditional risk markers for estimating prognosis in patients with stable coronary artery ...

Autonomic dysfunction and cardiac arrhythmia in patients with obstructive and central sleep apnea].

U Koehler, C Reinke, E Sibai... - Deutsche ..., 2011 - Obstructive sleep apnea and central sleep apnea with Cheyne-Stokes respiration are associated with an increased risk of cardiac arrhythmia. Apnea-associated arrhythmia may contribute to sudden cardiac death and premature mortality in those patients. Both forms ...
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