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Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3.

JD Burke, N Sonenberg, LC Platanias... - Antiviral therapy, 2011 - BACKGROUND: Viral myocarditis is most frequently associated with infection by Coxsackievirus B3 (CVB3). Interferon (IFN)-β therapy has been studied and could reduce virally induced tissue damage and improve heart function. METHODS: In the present study we have ...

... of Insulin Receptor Substrate-1 Genotypes on Platelet Reactivity and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease

DJ Angiolillo, E Bernardo, M Zanoni... - Journal of the ..., 2011 - Am Coll Cardio Found Objectives: The aim of this study was to assess the association between genetic variants of the insulin receptor substrate (IRS)-1 gene, platelet function, and long-term outcomes in patients with type 2 diabetes mellitus (DM) and stable coronary artery disease while on aspirin ...

Out-of-hospital pediatric cardiac arrest: Some clarifications needed

FW Moler, A Donaldson, K Meert... - Critical care medicine, 2011 - We are delighted at our Canadian colleagues' interest in our work and pleased to provide them with some additional information related to our paper, Multicenter cohort study of out-of-hospital pediatric cardiac arrest ( 1 ). This article was from data in our preclinical trial cohort study ...

A Comparison of Long-Term Mortality for Off-Pump and On-Pump Coronary Artery Bypass Graft Surgery

C Wu, FT Camacho, AT Culliford... - ... Quality and Outcomes, 2012 - Am Heart Assoc BackgroundThe survival difference between off-pump and on-pump coronary artery bypass graft surgery for follow-up longer than 5 years is not well-understood. The objective of this study is to examine the difference in 7-year mortality after these 2 procedures.

AAV6. βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

PWJ Raake, P Schlegel, J Ksienzyk... - European Heart ..., 2012 - Eur Soc Cardiology Aims G protein-coupled receptor kinase 2 (GRK2), which is markedly upregulated in failing human myocardium, has been implicated as a contributing factor or consequence of heart failure (HF). Importantly, cardiac-specific GRK2 knockout mice have recently proved the ...
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