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NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study

A Grntved, LB Andersen, PW Franks... - American Journal of ..., 2011 - Glu298Asp showed age-group-dependent associations with BP. In adolescents, Asp298 allele homozygotes had 0.19 sd (95% confidence interval (CI): 0.06; 0.13, P = 0.004) higher diastolic BP (DBP) and 0.25 sd (95% CI: 0.05; 0.46, P = 0.015) higher systolic BP (SBP), compared ...

Leukocyte Telomere Length Is Associated With Noninvasively Measured Age-Related Disease: The Cardiovascular Health Study

JL Sanders, AL Fitzpatrick... - The Journals ..., 2011 - biomedgerontology.oxfordjournals. ...Background. Most studies of leukocyte telomere length (LTL) focus on diagnosed disease in one system. A more encompassing depiction of health is disease burden, defined here as the sum of noninvasively measured markers of structure or function in different organ ...

Outcomes of Drug-Eluting Stents for Protected Left Main Coronary Artery Disease (from the Multicenter, United States DEScover Registry)

J Leitner, HA Vlachos, F Selzer, SM Jamal... - The American Journal of ..., 2011 - Elsevier Methods The DEScover is a prospective multicenter observational study designed to characterize patients with PCI from a broad sampling of hospitals and practices. Details of the study design have been previously described. 8 In brief, from January through June ...

A symptomatic esophageal mucocele after esophageal bypass surgery

K Minami, Y Toh, M Sugiyama, M Morita... - Esophagus, 2012 - Springer Abstract We encountered a case of esophageal mucocele with progressive respiratory symptoms which originated from an excluded thoracic esophagus that was closed at both the proximal and distal ends, and which occurred 24 years after esophageal bypass ...

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene

A Muchir, SA Reilly, W Wu... - Cardiovascular ..., 2012 - Aims Mutations in A-type nuclear lamins gene, LMNA, lead to a dilated cardiomyopathy. We have reported abnormal activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signalling in hearts from Lmna H222P/H222P mice, which develop dilated ...
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