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NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study
A Grntved, LB Andersen, PW Franks... - American Journal of ..., 2011 - Glu298Asp showed age-group-dependent associations with BP. In adolescents, Asp298 allele
homozygotes had 0.19 sd (95% confidence interval (CI): 0.06; 0.13, P = 0.004) higher diastolic
BP (DBP) and 0.25 sd (95% CI: 0.05; 0.46, P = 0.015) higher systolic BP (SBP), compared ...
Glu298 Asp showed age-group-dependent associations with BP. In adolescents, Asp298 allele homozygotes had 0.19 s.d. (95% confidence interval (CI): 0.06; 0.13, P = 0.004) higher diastolic BP (DBP) and 0.25 s.d. (95% CI: 0.05; 0.46, P = 0.015) higher systolic BP (SBP), compared to Glu298 allele carriers. None of the three other single-nucleotide polymorphisms (SN Ps) were associated with BP in adolescents. In children, none of the SN Ps were associated with BP. No evidence of interaction between Glu298 Asp and objectively measured PA was observed. Both self-reported bicycling and TV-viewing nominally modified the association between Glu298 Asp and BP in adolescents (P 0.05), the genetic effect being most apparent in inactive individuals. However, none of the interactions persisted after correcting for multiple testing.
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NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study |
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