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Insulin Resistance and Excess Risk of Diabetes in Mexican-Americans: The San Antonio Heart Study

C Lorenzo, HP Hazuda... - Journal of Clinical ..., 2011 - Endocrine Soc Abstract Context: Mexican-Americans have more diabetes than non-Hispanic whites, but the extent to which insulin resistance and insulin secretion explain the ethnic difference is unknown. Objective: We analyzed selected indices of insulin resistance and secretion for ...

Results: Incident diabetes was in excess in Mexican-Americans [odds ratio 2.26 (95% confidence interval, 1.53–3.34)]. Matsuda index explained a larger proportion of the ethnic difference than did HOMA-IR (49.2 vs. 31.0%; P < 0.001). The ethnic difference was not explained by measures of insulin secretion. Matsuda index and ΔI0–30/ΔG0–30 had a better predictive discrimination than their HOMA equivalents and ΔI0–120/ΔG0–120. HOMA estimates by the computer program offered no advantage over simple formulas for HOMA.