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Adiponectin: An independent risk factor for coronary heart disease in men in the Framingham offspring Study
M Ai, S Otokozawa, BF Asztalos, CC White... - Atherosclerosis, 2011 - Elsevier... b Department of Biostatistics, Boston University, Boston, MA, USA. c Framingham Heart Study,
Framingham, MA, USA. d Department of Medicine, Sumitomo General Hospital, Osaka, Japan.
Received 4 January 2011; revised 12 May 2011; accepted 27 May 2011. ...
Plasma adiponectin levels were measured in 3188 male and female participants from cycle 6 of the Framingham offspring Study (mean age: 57 years in both men and women; BMI: 28.5 kg/m2 in men and 27.3 kg/m2 in women), using a novel fully automated assay. Plasma adiponectin levels (median [25th percentile, 75th percentile]) were significantly higher in female than in male CHD-free subjects (14.8 [10.7,20.5] μg/ml versus 9.0 [7.0,12.2] μg/ml, p < 0.001). Participants were followed for a mean of 7.5 years. After adjustment for age, BMI, smoking status, systolic blood pressure, treatment for hypertension, diabetes, use of cholesterol-lowering medication, total cholesterol level, high-density lipoprotein cholesterol level, and C-reactive protein levels, a higher plasma adiponectin level was a significant predictor of lower risk of future CHD events (n = 117) in men (HR 0.49, p < 0.0022). A similar trend was observed in women, but was no longer significant after multivariate adjustments.
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Adiponectin: An independent risk factor for coronary heart disease in men in the Framingham offspring Study |
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