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Levosimendan in Two Neonates with Ischemic Heart Failure and Pulmonary Hypertension
MP De Carolis, M Piastra, I Bersani, M Pardeo... - ..., 2012 - We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart ...
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Levosimendan in Two Neonates with Ischemic Heart Failure and Pulmonary Hypertension Maria Pia De Carolisa, Marco Piastrab, Iliana Bersania, Manuela Pardeoc, Eleonora Stivalb, Alessia Temperad, Costantino Romagnolia, Giorgio Contib, Gabriella De Rosac a Neonatal ICU, Department of Pediatrics,b Pediatric ICU, Emergency Department, andc Pediatric Cardiology, Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, andd Neonatal ICU, S. Camillo-Forlanini Hospital, Rome, Italy
We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart malformation and/or previous cardiosurgical procedures. During the neonatal period, levosimendan may represent an ideal drug for immature myocardium characterized by a higher calcium-dependent contractility than in adults.
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Levosimendan in Two Neonates with Ischemic Heart Failure and Pulmonary Hypertension |
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