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Autoantibodies Against Serotoninergic 5-HT4 Receptor in Patients with Heart Failure.
M Breidert, S Wrdehoff, A Hansen... - ... and metabolic research ..., 2012 - Serotoninergic 5-HT4 receptors have been detected in several tissues including the heart. An autoimmune mechanism may underline the pathogenesis of heart failure. The aim of this work was to look for autoantibodies to the 5-HT4 receptor in patients with heart failure. We ...
Serotoninergic 5-HT(4) receptors have been detected in several tissues including the heart. An autoimmune mechanism may underline the pathogenesis of heart failure. The aim of this work was to look for autoantibodies to the 5-HT(4) receptor in patients with heart failure. We looked for the presence of autoantibodies against 5-HT(4) receptor as well as angiotensin II type (AT1), β(1)-adrenoceptor, and muscarinic M2 receptors in the sera of 176 patients with heart failure (female: n=96, male: n=80) and in 108 controls (female: n=69; male: n=39). The prevalence of 5-HT(4) receptor autoantibodies was 18.8% (n=33) in the group of patients with heart failure and 4.6% (n=5) in the control group (p Literature > Pub Med
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Autoantibodies Against Serotoninergic 5-HT4 Receptor in Patients with Heart Failure. |
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