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β-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure
G Ambrosio, MD Flather, M Bhm, A Cohen-Solal... - Heart, 2011 - Objectives This subanalysis of the Study of the Effects of Nebivolol Intervention on Outcomes
and Hospitalisation in Seniors with Heart Failure (SENIORS) investigates whether treatment
with nebivolol, a β-blocker with nitric oxide-releasing properties, can provide additional ...
Results At follow-up, nebivolol treatment was associated with a one-third reduction in the risk of ischaemic events, the composite endpoint occurring in 15.9% of placebo and 10.7% of nebivolol-treated patients (HR 0.68; 95% CI 0.51 to 0.90; p=0.008). This effect was independent of age, gender and ejection fraction. No difference in this composite endpoint was observed in the subgroup of patients of non-ischaemic aetiology.
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β-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure |
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