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04 The bronchodilator salbutamol is associated with increased myocardial injury in a pre-clinical heart attack model
A Nagra, H Maddock... - Heart, 2011 - Abstract Salbutamol is widely used to treat symptoms of chest tightness commonly associated with Asthma. Recent studies have associated increased in morbidity and mortality in asthmatic patients with underlying heart disease currently being treated with ...
Salbutamol is widely used to treat symptoms of chest tightness commonly associated with Asthma. Recent studies have associated increased in morbidity and mortality in asthmatic patients with underlying heart disease currently being treated with salbutamol. The study aimed to investigate the effects of salbutamol on the myocardium subjected to ischaemia-reperfusion (I/R). Langendorff hearts were subjected to control or I/R in the absence or presence of salbutamol (1–100 n M)±CGP-12177 (β1 adrenoceptor antagonist) or ICI 118551 (β2 adrenoceptor antagonist). Hearts underwent triphenyl tetrazolium staining for infarct size assessment. Isolated cardiomyocytes were exposed to simulated I/R in the absence or presence of salbutamol (1 p M–1 μM)±CGP-12177 or ICI 118551. Cellular injury was determined by measurement of viability, apoptosis and necrosis using flow cytometry. Hypercontracture was also assessed in cardiomyocytes subjected to oxidative stress in the absence or presence of salbutamol. Salbutamol (100 n M) significantly increased infarct size to risk ratio (%) compared to controls (76±3% vs 51±2%, p>
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04 The bronchodilator salbutamol is associated with increased myocardial injury in a pre-clinical heart attack model |
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