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Foxp3+ CD4+ CD25+ regulatory T cells are increased in patients with Coxiella burnetii endocarditis
C Layez, C Brunet, C Lpolard... - FEMS Immunology ..., 2011 - Wiley Online Library Abstract Chronic Q fever that principally manifests as endocarditis is characterized by Coxiella burnetii persistence and impaired cell-mediated immune response. The long-term persistence of pathogens has been associated with the expansion of regulatory T cells ( ... [PDF]
Chronic Q fever, which principally manifests as endocarditis, is characterized by Coxiella burnetii persistence and an impaired cell mediated immune response. The long term persistence of pathogens has been associated with the expansion of regulatory T cells (Tregs), the CD4+T cell subset that is characterized by the expression of CD25 and Foxp3. We investigated the presence of Tregs in patients with acute Q fever (n = 17), known to exhibit an efficient immune response, patients with Q fever endocarditis (n = 54) and controls (n = 27) by flow cytometry. The proportion of CD3+, CD4+ and CD8+T cells was similar in controls and patients with Q fever. The percentage of CD4+T cells that expressed CD25 was similar in controls and patients with Q fever. The population of CD4+T cells that expressed both CD25 and Foxp3 was significantly (P < 0.001) increased in patients with Q fever endocarditis compared with controls. Our data suggest that the expansion of Tregs may be critical for the chronic evolution of Q fever.
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Foxp3+ CD4+ CD25+ regulatory T cells are increased in patients with Coxiella burnetii endocarditis |
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