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Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 ...

S Camastra, A Gastaldelli, A Mari, S Bonuccelli... - Diabetologia, 2011 - Springer Abstract Aims/hypothesis Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. Methods We studied 25 morbidly obese patients (BMI 51.71.5 kg/m 2 [meanSEM]), 13 ...

Arrhythmia Formation in Subclinical (“Silent”) Long QT Syndrome Requires Multiple Insults: Quantitative Mechanistic Study Using the KCNQ1 Mutation Q357R as ...

T O'Hara... - Heart Rhythm, 2011 - Elsevier Background In subclinical, or silentlong QT syndrome (LQTS), the QT interval is normal under basal conditions. The hypothesis thatinsults to the repolarization reserve may cause arrhythmias insilent mutation carriers, but not in non-carriers, has been proposed as a ...

Adherence to a Low-Risk, Healthy Lifestyle and Risk of Sudden Cardiac Death Among Women

SE Chiuve, TT Fung, KM Rexrode... - JAMA: The Journal of ..., 2011 - Am Med Assoc Abstract Context Sudden cardiac death (SCD) accounts for more than half of all cardiac deaths; the majority of SCD events occur as the first manifestation of heart disease, especially among women. Primary preventive strategies are needed to reduce SCD ...

Sedentary Behavior and Adiposity-Associated Inflammation: The Multi-Ethnic Study of Atherosclerosis

MA Allison, NE Jensky, SJ Marshall... - American Journal of ..., 2012 - Elsevier BACKGROUND: Sedentary behavior is associated with adiposity and cardiometabolic risk. PURPOSE: To determine the associations between sedentary behavior and measures of adiposity-associated inflammation. METHODS: Between 2002 and 2005, a total of 1543 ... [PDF]

G Protein–Coupled Receptor Kinase-5 Attenuates Atherosclerosis by Regulating Receptor Tyrosine Kinases and 7-Transmembrane Receptors

JH Wu, L Zhang, AC Fanaroff, X Cai... - ... and Vascular Biology, 2012 - Am Heart Assoc ObjectiveG proteincoupled receptor kinase-5 (GRK5) is a widely expressed Ser/Thr kinase that regulates several atherogenic receptors and may activate or inhibit nuclear factor-κB (NF-κB). This study sought to determine whether and by what mechanisms GRK5 ...
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