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Darbepoetin improves endothelial function and increases circulating endothelial progenitor cell number in patients with coronary artery disease
C Mueller, K Wodack, K Twelker, N Werner... - Heart, 2011 - Background Atherosclerosis is a progressive disease characterised in part by an imbalance
of endothelial decline and endothelial repair. Erythropoietin has been connected to vasculoprotective
effects such as enhanced nitric oxide production in endothelial cells and mobilisation of ...
Methods 20 Patients with stable coronary artery disease receiving optimal medical treatment with either weekly subcutaneous injections of saline (placebo) or the recombinant erythropoietin darbepoetin (60 μg/injection) over 3 consecutive weeks. At the initial and final visits, flow mediated dilatation (FMD) was determined by ultrasound. The number of EPC was determined as the number of CD34/CD133 positive mononuclear cells in peripheral blood.
More Details:
Darbepoetin improves endothelial function and increases circulating endothelial progenitor cell number in patients with coronary artery disease |
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