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Association between< i> adiponectin</i> gene polymorphisms and coronary artery disease across different populations
L Zhou, B Xi, Y Wei, H Pan, W Yang, W Shen... - Thrombosis ..., 2012 - Elsevier Objective Many studies have suggested that adiponectin gene might be involved in the development of coronary artery disease (CAD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the ...
Many studies have suggested that adiponectin gene might be involved in the development of coronary artery disease (CAD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the associations of + 45T/G, + 276G/T and 11377C/G polymorphisms in adiponectin gene with CAD susceptibility.
Sixteen studies (4394 cases / 8187 controls) for + 45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for + 276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for 11377C/G polymorphism were included in the meta-analysis. The overall results showed that there was a statistically significant association between 11377C/G polymorphism and CAD (G vs. C: OR = 1.15, 95%CI 1.07-1.24).Similar results were observed among European (G vs. C: OR = 1.11, 95%CI 1.02-1.20) and East Asian populations (G vs. C: OR = 1.27, 95%CI 1.11-1.45). However, no significant association was found for + 45T/G or + 276G/T polymorphism with CAD susceptibility.
The meta-analysis indicated the significant association of 11377C/G polymorphism, but not + 45T/G or + 276G/T polymorphism, with CAD susceptibility. However, large-scale studies with the consideration of gene-gene and gene-environment interactions should be conducted to investigate the associations in future.
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Association between< i> adiponectin</i> gene polymorphisms and coronary artery disease across different populations |
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