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Stroke After Coronary Artery Bypass Graft Surgery—Reply
JF Sabik... - JAMA: The Journal of the American ..., 2011 - Am Med Assoc In Reply: As Dr Fan and colleagues discuss, and we stated as a limitation of our study, we did not report whether the perioperative strokes were due to embolism, thrombosis, hemorrhage, or hypoperfusion. These data are not routinely captured in our prospective ...
Because of the negative concordance of 3 of in-total 8 tests studied in the Popular study (the platelet function analysis [PFA] collagen/adenosine diphosphate [ADP] cartridge, the Innovance PFA P2Y, and the IMPACT-R ADP test), the initially calculated receiver operating characteristic (ROC) curves were mirrored, leading to the incorrect optimal cutoff value. Consequently, the cutoff values we reported for these 3 tests were incorrect. This error was brought to our attention by a staff member of Siemens Healthcare Diagnostics Products (Marburg, Germany) who had access to the data set related to the Innovance PFA P2Y, because this cartridge was under development at the time of inclusion in the Popular study. Because Siemens used another statistics program (SAS; SAS Institute, Cary, North Carolina) in which the ROC curve was mirrored prior to the calculation of the cutoff value, another cutoff value for this cartridge was derived. After careful recalculation, we confirmed that our cutoff value was erroneous and that the same error was made in calculating the cutoff values of the IMPACT-R ADP as well as the PFA COL/ADP. We regret to report that this error was overlooked despite careful review by the principal investigators, the statistician, and the coauthors.
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Stroke After Coronary Artery Bypass Graft Surgery—Reply |
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