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Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system.
SS Chen, CS Tang, HF Jin... - Chinese medical journal, 2011 - OBJECTIVE: Sulfur dioxide was considered to be toxic and detrimental to human health.
However, this review highlights recent advances that suggest sulfur dioxide might be a novel
endogenous gaseous signaling molecule involved in the regulation of cardiovascular ...
The sulfur dioxide/aspartate amino transferase pathway is endogenously generated in the cardiovascular system, and sulfur dioxide shows broad bioactive effects, such as antihypertension, vasodilation, and amelioration of vascular remodeling. A disturbed sulfur dioxide/aspartate amino transferase pathway is known to be involved in the pathogenesis of many cardiovascular diseases, such as ischemia-reperfusion injury, monocrotaline-induced pulmonary hypertension, athrosclerosis, spontaneous hypertension and hypoxic pulmonary hypertension. Furthermore, in experimental studies the prognosis of these cardiovascular diseases can be improved by targeting endogenous sulfur dioxide.
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Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system. |
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