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Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system
A Stangherlin... - American Journal of Physiology- ..., 2011 - Am Physiological Soc Abstract Phosphodiesterases (PDEs) are key enzymes in the c AMP signaling cascade. They convert c AMP in its inactive form 5'-AMP and critically regulate the intensity and the duration of c AMP-mediated signals. Multiple isoforms exist that possess different intracellular ...
Phosphodiesterases (PD Es) are key enzymes in the c AMP signaling cascade. They convert c AMP in its inactive form 5'-AMP and critically regulate the intensity and the duration of c AMP-mediated signals. Multiple isoforms exist that possess different intracellular distributions, different affinities for c AMP, and different catalytic and regulatory properties. This complex repertoire of enzymes provides a multiplicity of ways to modulate c AMP levels, to integrate more signaling pathways and to respond to the specific needs of the cell within distinct subcellular domains. In this review we summarize key findings on PDE compartmentalization in the cardiovascular system.
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Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system |
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