Heart Care Info - Heart Disease Prevention & Treatment

Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy

C Marchesi, R Essalmani, CA Lemari... - Journal of Molecular ..., 2011 - Springer Abstract Proprotein convertase (PC) 5/6 belongs to a family of secretory proteases involved in proprotein proteolysis. Several studies suggest a role for PC5/6 in cardiovascular disease. Because lethality at birth of mice lacking PC5/6 precluded elucidation of its function in the ...