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Parental Smoking in Childhood and Brachial Artery Flow-Mediated Dilatation in Young Adults: The Cardiovascular Risk in Young Finns Study and the Childhood ...

M Juonala, CG Magnussen, A Venn... - ... and Vascular Biology, 2012 - Am Heart Assoc Page 1. Parental Smoking in Childhood and Brachial Artery Flow-Mediated Dilatation in Young Adults: The Cardiovascular Risk in Young Finns Study and the Childhood Determinants of Adult Health Study Markus Juonala, Costan ... [HTML]

Methods and Results—The analyses were based on 2171 participants in the population-based Cardiovascular Risk in Young Finns (N=2067) and Childhood Determinants of Adult Health (N=104) studies who had measures of conventional risk factors (lipids, blood pressure, adiposity, socioeconomic status) and self-reported parental smoking status when aged 3 to 18 years at baseline. They were re-examined 19 to 27 years later when aged 28 to 45 years. Brachial artery flow-mediated dilatation was measured at follow-up with ultrasound. In analyses adjusting for age, sex, and childhood risk factors, flow-mediated dilatation was reduced among participants who had parents that smoked in youth compared to those whose parents did not smoke (Young Finns: 9.2±0.1% (mean±SEM) versus 8.6±0.1%, P=0.001; Childhood Determinants of Adult Health: 7.4±0.6% versus 4.9±0.9%, P=0.04). These effects remained after adjustment for adult risk factors including own smoking status (Young Finns, P=0.003; Childhood Determinants of Adult Health, P=0.03).