Heart Care Info - Heart Disease Prevention & Treatment

Targeting cardiovascular disease with novel SIRT1 pathways

ZZ Chong, S Wang, YC Shang... - Future Cardiology, 2012 - Future Medicine Sirtuin (the mammalian homolog of silent information regulation 2 of yeast Saccharomyces cerevisiae) 1 (SIRT1), a NAD-dependent histone deacetylase, has emerged as a critical regulator in response to oxidative stress. Through antagonism of oxidative stress-induced ...