Heart Care Info - Heart Disease Prevention & Treatment

... Intakes of Zinc and Heme Iron from Red Meat, but Not from Other Sources, Are Associated with Greater Risk of Metabolic Syndrome and Cardiovascular Disease

MC de Oliveira Otto, A Alonso, DH Lee... - The Journal of ..., 2012 - Am Soc Nutrition Abstract Met S, T2D, and CVD share an inflammatory etiology and are known to be influenced by diet. We investigated associations of hypothesized prooxidative (Fe) and antioxidative (Zn, Mg, β-carotene, vitamin C, vitamin E) micronutrients with incident Met S, ...

Met S, T2D, and CVD share an inflammatory etiology and are known to be influenced by diet. We investigated associations of hypothesized prooxidative (Fe) and antioxidative (Zn, Mg, β-carotene, vitamin C, vitamin E) micronutrients with incident Met S, T2D, and CVD in the Multi-Ethnic Study of Atherosclerosis. Participants, 45–84 y at baseline (2000–2002), were followed through 2010. Diet was assessed by FFQ. After adjusting for demographics and behavioral confounders, including BMI, dietary vitamin E intake was inversely associated with incident Met S and CVD [HR for extreme quintiles: Met S = 0.78 (95% CI = 0.62, 0.97), P-trend = 0.01; CVD: HR = 0.69 (95% CI = 0.46, 1.03), P-trend = 0.04]. Intakes of heme iron and Zn from red meat, but not from other sources, were positively associated with risk of Met S [heme iron from red meat: HR = 1.25 (95% CI = 0.99,1.56), P-trend = 0.03; Zn from red meat: HR = 1.29 (95% CI = 1.03,1.61), P-trend = 0.04] and CVD [heme iron from red meat: HR = 1.65 (95% CI = 1.10,2.47), P-trend = 0.01; Zn from red meat: HR = 1.51 (95% CI = 1.02, 2.24), P-trend = 0.01]. Dietary intakes of nonheme iron, Mg, vitamin C, and β-carotene were not associated with risk of Met S, T2D, or CVD. Data provided little support for the associations between specific micronutrients and Met S, T2D, or CVD. However, nutrients consumed in red meat, or red meat as a whole, may increase risk of Met S and CVD.