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Activin A and cardiovascular disease in type 2 diabetes mellitus
T Ueland, P Aukrust, S Aakhus... - Diabetes and ..., 2012 - Background: Silent coronary artery disease is a frequent complication of type 2 diabetes (T2DM). Based on its multiple roles in inflammation, atherogenesis and glucose homeostasis, we hypothesised that activin A could be related to coronary atherosclerosis ...
Results: Serum activin A and the activin A/follistatin ratio were increased in patients with T2DM and coronary artery disease (CAD) compared with healthy volunteers and the elevated activin A was associated with the severity of coronary atherosclerotic burden as determined by the proportion of ≥2 vessel disease (p = 0.035) after multivariable-adjusted trend analysis. No significant association between presence of CAD or extent score and activin A was observed.
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Activin A and cardiovascular disease in type 2 diabetes mellitus |
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