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Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene
W Wu, A Muchir, J Shan, G Bonne... - Circulation, 2011 - Am Heart Assoc Background Mutations in the lamin A/C gene, LMNA, can cause dilated cardiomyopathy. We
have shown abnormal activation of the extracellular signal-regulated kinase (ERK) and the
c-jun N-terminal kinase (JNK) branches of the mitogen-activated protein kinase signaling ...
From the Department of Medicine (W.W., A.M., H.J.W.), Department of Pathology and Cell Biology (W.W., A.M., H.J.W.), Department of Physiology and Cellular Biophysics (J.S.), and Clyde and Helen Wu Center for Molecular Cardiology (J.S.), College of Physicians and Surgeons, Columbia University, New York, NY; and INSERM, U974 (G.B.), Université Pierre et Marie Curie-Paris, UMR-S974, CNRS, UMR-7215, Institut de Myologie, IFR14 (G.B.), and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, U.F. Cardiogénétique et Myogénétique, Service de Biochimie Métabolique (G.B.), Paris, France.
Correspondence to Antoine Muchir, Ph D, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th St, 10th Floor, Room 518, New York, NY 10032 (E-mail am2434{at}columbia.edu); or Howard J. Worman, MD, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th St, 10th Floor, Room 508, New York, NY 10032 (E-mail hjw14{at}columbia.edu).
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Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene |
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