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Aliskiren attenuates myocardial apoptosis and oxidative stress in chronic murine model of cardiomyopathy

A Rashikh, SJ Ahmad, KK Pillai, K Kohli... - Biomedicine & ..., 2012 - Elsevier Abstract Doxorubicin (DXR) is one of the most effective antineoplastic agents. However, the optimal clinical use of this agent is limited because of marked cardiomyopathy and congestive heart failure. Renin angiotensin system (RAS) plays an important role in the ...

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

PK Battiprolu, B Hojayev, N Jiang... - The Journal of ..., 2012 - Am Soc Clin Investig Pavan K. Battiprolu 1, Berdymammet Hojayev 1, Nan Jiang 1, Zhao V. Wang 1, Xiang Luo 1, Myriam Iglewski 1, John M. Shelton 1, Robert D. Gerard 1, Beverly A. Rothermel 1, Thomas G. Gillette 1, Sergio Lavandero 1, 2 and Joseph A. Hill 1, 3 [CITATION] Cardiac-Targeted TRPM7 Deletion Induces Heart Block and Cardiomyopathy via Disrupted Embryonic Ventricular Development R Sah, C Bates-Withers, X Mason... - Biophysical Journal, 2012 - Elsevier

Long-Term Outcomes in Hypertrophic Cardiomyopathy Caused by Mutations in the Cardiac Troponin T GeneClinical Perspective

F Pasquale, P Syrris, JP Kaski... - Circulation: ..., 2012 - Am Heart Assoc BackgroundHypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene (TNNT2) has been associated with a high risk of sudden cardiac death (SCD) and mild left ventricular hypertrophy. However, previous studies are limited by sample size, cross- ...

Cardiomyopathy with Inverted Tako-Tsubo Pattern in the Setting of Subarachnoid Hemorrhage: A Series of Four Cases

S Shoukat, A Awad, DK Nam, MH Hoskins... - Neurocritical Care, 2012 - Springer Abstract Background Severe subarachnoid hemorrhage may be associated with regional wall motion abnormalities (RWMA) in the absence of epicardial coronary occlusion. The RWMA extends beyond the distribution of a single coronary artery and may present in a ...

Echocardiographic quantification of regional deformation helps to distinguish isolated left ventricular non-compaction from dilated cardiomyopathy

M Niemann, D Liu, K Hu, M Cikes... - ... journal of heart ..., 2012 - Aims Pronounced trabeculation is presented in both left ventricular non-compaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation difficult. We hypothesized that echocardiographic deformation analysis would help to differentiate ...

Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: An integrative in silico-in vitro ...

EP Manning, PJ Guinto... - Journal of Biological Chemistry, 2012 - ASBMBBackground: Cardiomyopathy-causing mutations in the N-terminal domain of c Tn T disrupt thin filament function. Results: Amino acid substitutions at c Tn T Residue 92 alter motility while computational analysis reveals significant changes in structural forces. Conclusion: ...
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