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Predictors of Sudden Cardiac Death: A Competing Risk Approach in the Hemodialysis Study
S Shastri, N Tangri, H Tighiouart... - Clinical Journal of the ..., 2012 - Am Soc Nephrol Summary Background and objectives There are few data on risk factors for sudden cardiac death (SCD) in patients undergoing hemodialysis (HD). The study objective was to identify predictors associated with various causes of death in the Hemodialysis (HEMO) Study and ...
Results During a median follow-up of 2.5 years, 808 patients died. Rates of SCD, non-SCD, and noncardiac death were 22%, 17%, and 61%, respectively. Predictors of various causes of death differ somewhat in HD patients. Age, diabetes, peripheral vascular disease, ischemic heart disease, serum creatinine, and alkaline phosphatase were independent predictors of SCD. The 3-year C-statistic for SCD was 0.75 (95% confidence interval, 0.70–0.79), and calibration was good (χ2=1.1; P=0.89). At years 3 and 5 of follow-up, the standard Cox model overestimated the risk for SCD as compared with the competing risk approach on the relative scale by 25% and 46%, respectively, and on the absolute scale by 2% and 6%, respectively.
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Predictors of Sudden Cardiac Death: A Competing Risk Approach in the Hemodialysis Study |
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