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A Common Variant in the Beta-2 Adrenergic Receptor and Risk of Sudden Cardiac Death
MC Gavin, C Newton-Cheh, JM Gaziano, NR Cook... - Heart Rhythm, 2011 - Elsevier Homozygosity for the Gln27 allele conferred a non-significant elevation of the age-adjusted odds
ratio (OR=1.22; 95% CI, 0.98-1.53; P=0.08) for SCD, which became marginally significant after
controlling for multiple cardiac risk factors (OR=1.30, 95% CI: 1.01-1.67; P=0.046). In ...
Nested case-control analysis was performed for individuals of Caucasian ancestry enrolled in six prospective cohort studies. Genotypes for the Gln27 Glu variant were determined for 492 cases of SCD and 1,388 controls matched for age, sex, cohort, follow-up time, and history of cardiovascular disease (CVD) and at the time of the blood draw. Individual studies were combined with conditional logistic regression with fixed effects meta-analysis assuming a recessive model.
Homozygosity for the Gln27 allele conferred a nonsignificant elevation of the age-adjusted odds ratio (OR 1.22, 95% confidence interval [CI] 0.98 1.53, P = .08) for SCD, which became marginally significant after controlling for multiple cardiac risk factors (OR 1.30, 95% CI 1.01 1.67, P = .046). In secondary analyses using controls additionally matched for the development of nonfatal CVD after the blood draw, results were attenuated (OR 1.19, 95% CI 0.92 1.52, P = .19). When the results of the primary analysis were combined in meta-analysis with published reports, a significant association between ADRB2 genotype and SCD emerged (OR 1.35, 95% CI 1.15 1.60, P = .0003).
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A Common Variant in the Beta-2 Adrenergic Receptor and Risk of Sudden Cardiac Death |
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