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Reply to Letters Regarding Article,“Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest”
JH Kilgannon, S Trzeciak, JE Parrillo... - Circulation, 2012 - Am Heart Assoc We thank Drs Cornet and Bellomo and colleagues for their interest in the topic of hyperoxia exposure after resuscitation from cardiac arrest. Regarding the letter from Cornet et al, we used a different definition of hypoxia as a result of the peer review process, in which we ...
We thank Drs Cornet and Bellomo and colleagues for their interest in the topic of hyperoxia exposure after resuscitation from cardiac arrest. Regarding the letter from Cornet et al, we used a different definition of hypoxia as a result of the peer review process, in which we were asked by a reviewer to liberalize the definition of normoxia in order to minimize restriction of the sample and thus yield results that were generalizable to as many post–cardiac arrest patients as possible. Regarding the letter from Bellomo et al, we decided a priori to base the analysis on the measured partial pressure of arterial oxygen (Pao2), which we feel is the true “exposure” in this type of study, and not on the reported fraction of inspired oxygen (Fio2) on the grounds that Fio2 and Pao2 must exhibit collinearity, and thus including both variables in the regression model could be expected to attenuate an association between exposure and outcome.
Regarding severity of illness, our multivariable modeling procedure did adjust for a number of individual elements that comprise the Acute Physiology and Chronic Health Evaluation (APACHE) scoring system (eg, vital signs and chronic health conditions). We decided a priori not to additionally adjust for the APACHE score on the grounds that APACHE scores were not a mandatory element of data collection, and considerable restriction of the sample would have been required for the multivariable analysis. But at your request, we provide this information now (n=3064). ...
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Reply to Letters Regarding Article,“Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest” |
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