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Anti-CD3 treatment cures PDL1-/-. NOD mice of diabetes but precipitates fatal myocarditis

B Mfarrej, M Keir, S Dada, S Trikudanathan... - Clinical ..., 2011 - Elsevier Anti-CD3 m Ab is an effective therapy that can reverse diabetes in NOD mice and has therapeutic potential in patients with type 1 diabetes (T1D). We administered anti-CD3 to PDL1−/−.NOD mice in order to determine whether this treatment would reverse the development of ...

Prediction of Heart Failure and Adverse Cardiovascular Events in Outpatients with Coronary Artery Disease Using Mitral E/A Ratio in Conjunction with E-Wave ...

RK Mishra, RB Devereux, BE Cohen... - Journal of the American ..., 2011 - Elsevier Deceleration time (DT) of early mitral inflow (E) is a marker of diastolic left ventricular (LV) chamber stiffness that is routinely measured during the quantitation of LV diastolic function with Doppler echocardiography. Shortened DT after myocardial infarction predicts worse ...

Reducing Personal Exposure To Particulate Air Pollution Improves Cardiovascular Health In Patients With Coronary Heart Disease

JP Langrish, X Li, S Wang... - Environmental ..., 2012 - Background. Air pollution exposure increases cardiovascular morbidity and mortality, and is a major global public health concern. Objectives. To investigate the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease. Methods. ...

... of exercise training on diastolic function in heart failure with reduced ejection fraction: The Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) ...

M Sandri, I Kozarez, V Adams... - European Heart ..., 2012 - Eur Soc Cardiology Aims Diastolic dysfunction (DD) was identified as a predictor of adverse prognosis in heart failure with reduced ejection fraction (HFREF). It is, however, unknown if DD is improved by exercise training, which is known to induce reverse remodelling, and if the training effect is ...

Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: The Leipzig Exercise Intervention in Chronic Heart Failure ...

M Sandri, I Kozarez, V Adams... - European Heart ..., 2012 - Eur Soc Cardiology... 17 These observations were corroborated by state-of-the-art tissue Doppler measurements in the Ume Heart Study where a marked decrease in early diastolic velocities was recorded with age (from 16 cm/s at 30 years to 9 cm/s at 80 years) accompanied by a corresponding ...
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