Heart Care Info - Heart Disease Prevention & Treatment

Subcutaneous adipose tissue blood flow and vasomotion in morbidly obese patients: Long term effect of gastric bypass surgery

M Rossi, M Nannipieri, M Anselmino... - Clinical Hemorheology ..., 2012 - IOS Press Since recent findings suggest a relationship between reduction in adipose tissue blood flow and metabolic or vascular complications of obesity, increase in ATBF may be considered as a further goal in the treatment of obesity, besides fat mass reduction. Therefore, this ...

Since recent findings suggest a relationship between reduction in adipose tissue blood flow and metabolic or vascular complications of obesity, increase in ATBF may be considered as a further goal in the treatment of obesity, besides fat mass reduction. Therefore, this preliminary study aimed at assess subcutaneous ATBF and vasomotion in morbidly obese patients (Ob-pts) and whether sustained weight loss induced by Roux-en-Y gastric bypass (RYGB) affects the same parameters. Using laser-Doppler flowmetry (LDF) and spectral Fourier analysis, subcutaneous ATBF was measured and subcutaneous ATBF oscillations (ATBF-O) were analyzed in 16 Ob-pts, before and about one year after RYGB, and in 10 lean, healthy control subjects (CS). Before RYGB, Ob-Pts showed an important reduction in subcutaneous ATBF compared to CS (4.8 ± 2.7 PU vs 79.9 + 34.5 PU, respectively; p < 0.0001), as well as higher normalized power spectral density (N-PSD) values of subcutaneous ATBF-O. One year after RYGB, sustained weight loss in Ob-pts was associated with a slight but significant increase in subcutaneous ATBF (10.0 ± 6.6 PU, p < 0.05) and with almost complete normalization in N-PSD values of ATBF-O, compared to before RYGB. The slight subcutaneous ATBF increase, we observed in Ob-pts after sustained weight loss, moves toward a desirable goal. This finding suggests verifying whether an even more sustained weight loss in Ob-pts could determine a greater increase in subcutaneous ATBF and/or, more importantly, it could also determine a significant increase in visceral ATBF.