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Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides
Y Falkn, PM Hellstrm, JJ Holst... - Journal of Clinical ..., 2011 - Endocrine Soc Method: Twelve obese subjects (body mass index 45.3 1.9 kg/m 2 ) were subjected to a liquid
meal without lipids before and 3 d, 2 months, and 1 yr after GBP. Plasma concentrations of
glucose, insulin, leptin, and gut peptide hormones were assessed before and for 180 min ...
Results: All subjects lost weight (body mass index 30.3 ± 1.8 kg/m2 at 1 yr). Fasting glucose was significantly lower on d 3 (P < 0.05). There was a progressive decrease in the homeostasis model assessment of insulin resistance after 2 months postoperatively. Postprandially, there was a progressive rise of GLP-1 and enteroglucagon and a transient increase in pancreatic glucagon release over the study period. There was a leftward shift of the time course of plasma glucose and insulin. Somatostatin release was lower on d 3 (P < 0.05) but then unchanged. The absorption rate of acetaminophen was twice as fast after GBP compared with before surgery and did not change over time. Satiety scores increased markedly postoperatively.
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Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides |
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