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... wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling
L Conde, S Bevan, M Sitzer, N Klopp, T Illig... - Atherosclerosis, 2011 - Elsevier Background Recent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT ...
Recent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT) is a measure of early arterial remodeling and arteriosclerosis. Therefore, if CAD associated SN Ps are also associated with carotid IMT; it suggests that they are acting via the early stages of the atherosclerotic process.
In three large community based independent populations (CAPS, KORA and Young Finns) of European ancestry in which common carotid IMT had been measured (total 4961 individuals), we determined whether SN Ps that have been associated with CAD in GWAS studies are also associated with carotid IMT. Associations with plaque were not examined.
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... wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling |
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