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White blood cell count is associated with carotid and femoral atherosclerosis
E Ortega, R Gilabert, I Nuez, M Cofn... - Atherosclerosis, 2012 - Elsevier OBJECTIVE: Chronic low-grade inflammation is associated with atherosclerosis. Ultrasound imaging allows measurement of intima-media thickness (IMT) and plaque. We investigated the association between inflammatory markers and carotid and femoral atherosclerosis. ... [CITATION] Erratum to Predictive value of white blood cell subtypes for long-term outcome following myocardial infarctions[Atherosclerosis 196 (2008) 405412]R Dragu, S Khoury, R Zuckerman, M Suleiman... - Atherosclerosis, 2012 - Elsevier
We studied 554 subjects with primary dyslipidemia (57% men, median age 49 years) and 246 age- and sex-matched normolipidemic subjects. Carotid and femoral arteries were imaged bilaterally with a standardized protocol. Mean and maximum common carotid IMT (CC-IMT and Max CC-IMT) and common femoral IMT (F-IMT and Max F-IMT), and carotid and femoral plaque were assessed. Carotid atherosclerosis was defined by CC-IMT and/or plaque height >75th percentile of a reference population. White blood cell count (WBCC) was measured in all subjects. High-sensitivity C-reactive protein (CRP) was measured in 330 dyslipidemic subjects.
The age- and sex-adjusted probability of carotid atherosclerosis and femoral plaque increased by 20% (odds ratio [OR] 1.20; 95% CI, 1.10 1.31) and 25% (1.25; 1.13 1.38), respectively, for each 1000/mm3 WBCC increment. WBCC was associated with age- and sex-adjusted CC-IMT and Max CC-IMT (p < 0.05, both), and F-IMT and Max F-IMT (p < 0.001, both). Adjustment for cardiovascular risk factors did not influence these associations. CRP was associated with CC-IMT and Max CC-IMT (p < 0.05, both), but the associations disappeared after adjustment for body mass index. CRP was unrelated to carotid plaque or measures of femoral atherosclerosis.
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White blood cell count is associated with carotid and femoral atherosclerosis |
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