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The Relationship between Resting Heart Rate and Incidence and Progression of Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis (MESA)
J Rubin, MJ Blaha, MJ Budoff, JJ Rivera, LJ Shaw... - Atherosclerosis, 2011 - Elsevier Our study population consisted of 6,004 individuals (62 10 years, 48% males). Among 3,079
individuals with no detectable CAC at baseline, 20% (n = 620) developed CAC. After adjusting
for CVD risk factors, participants with a baseline resting heart rate >80 bpm had an ...
Elevated resting heart rate has been independently associated with cardiovascular and all-cause mortality. The pathophysiological mechanisms by which this increased risk occurs are unclear. We hypothesized that elevated resting heart rate will be associated with increased development of atherosclerosis, as assessed by the incidence and progression of coronary artery calcium (CAC).
The Multi-Ethnic Study of Atherosclerosis is a prospective cohort study of participants free of clinical cardiovascular disease at entry. Among persons without CAC at baseline, the association between increasing clinical categories of heart rate (80 bpm) and CAC incidence was assessed by relative risk regression after adjusting for covariates. Among those with detectable CAC at baseline, progression of CAC was assessed using multivariable robust linear regression.
Our study population consisted of 6004 individuals (62 10 years, 48% males). Among 3079 individuals with no detectable CAC at baseline, 20% (n = 620) developed CAC. After adjusting for CVD risk factors, participants with a baseline resting heart rate >80 bpm had an increased risk of incident CAC as compared to those with a resting heart rate 80 bpm had greater CAC score progression than those with a resting heart rate 0 at baseline, by heart rate category and race/ethnicity. Participants with baseline heart rate above 80 bpm had greater progression of CAC as compared with those in lower heart rate categories. When stratified by self-identified race, the trend of greater progression of CAC among those with elevated HR persisted.
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The Relationship between Resting Heart Rate and Incidence and Progression of Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis (MESA) |
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