Heart Care Info - Heart Disease Prevention & Treatment

Studies of aging, metabolism and the age-dependent disease atherosclerosis in mouse mutants with altered mitochondrial function

B Hughes - 2012 - Abstract: Mutational disruption of the genes clk-1 and isp-1, the products of which are involved in mitochondrial oxidative phosphorylation, has been shown to extend lifespan in the nematode worm Caenorhabditis elegans. Here, we describe efforts to characterize the ...