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Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms
X Xie, W Chen, Y Wang, S Zhang, H Bi, B Hong... - Atherosclerosis, 2011 - Elsevier OBJECTIVE: Statins reduce atherosclerosis, but it is controversial whether they suppress abdominal aortic aneurysm (AAA) expansion. We hypothesized that statins (rosuvastatin and atorvastatin) would attenuate angiotensin II (Ang II)-induced atherosclerosis and AAA. ...
Sixty apo E / male mice fed a normal diet were administered with either rosuvastatin (10 mg/kg/day) or atorvastatin (20 mg/kg/day) through drinking water for 1 week prior to initiating 28-day Ang II infusion (1000 ng/kg/min). Statins administration led to therapeutic serum concentrations of drugs. Administration of either rosuvastatin or atorvastatin exerted no significant effect on Ang II-induced expansion of suprarenal diameter or area. However, atorvastatin significantly reduced Ang II-augmented atherosclerotic lesion areas in intimas of both aortic arches and cross-sections of aortic roots (P < 0.001). Atherosclerosis was attenuated independent of reductions in serum total cholesterol concentrations. Although serum MCP-1 and MIF concentrations were not changed by either statins, atorvastatin administration increased PPAR-α and -γ m RNA abundances and decreased NF-κB p50, p65, MCP-1 and TNF-α m RNA abundances in atherosclerotic lesions.
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Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms |
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