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Free fatty acids are associated with insulin resistance but not coronary artery atherosclerosis in rheumatoid arthritis
MJ Ormseth, LL Swift, S Fazio, MRF Linton... - Atherosclerosis, 2011 - Elsevier Background Free fatty acids (FFAs) affect insulin signaling and are implicated in the pathogenesis of insulin resistance and atherosclerosis. Inflammatory cytokines such as interleukin-6 (IL-6) increase lipolysis and thus levels of FFAs. We hypothesized that ...
Free fatty acids (FF As) affect insulin signaling and are implicated in the pathogenesis of insulin resistance and atherosclerosis. Inflammatory cytokines such as interleukin-6 (IL-6) increase lipolysis and thus levels of FF As. We hypothesized that increased IL-6 concentrations are associated with increased FF As resulting in insulin resistance and atherosclerosis in rheumatoid arthritis (RA).
Clinical variables, serum FF As and inflammatory cytokines, homeostasis model assessment for insulin resistance (HOMA-IR), and coronary artery calcium were measured in 166 patients with RA and 92 controls. We compared serum FF As in RA and controls using Wilcoxon rank sum tests and further tested for multivariable association by adjusting for age, race, sex and BMI. Among patients with RA, we assessed the relationship between serum FF As and inflammatory cytokines, HOMA-IR, and coronary artery calcium scores using Spearman correlation and multivariable regression analyses.
Serum FF As did not differ significantly in patients with RA and controls (0.56 mmol/L [0.38 0.75] and 0.56 mmol/L [0.45 0.70] respectively, p = 0.75). Presence of metabolic syndrome was associated with significantly increased serum FF As in both RA and controls (p = 0.035 and p = 0.025). In multivariable regression analysis that adjusted for age, race, sex and BMI, serum FF As were associated with HOMA-IR (p = 0.011), CRP (p = 0.01), triglycerides (p = 0.005) and Framingham risk score (p = 0.048) in RA, but not with IL-6 (p = 0.48) or coronary artery calcium score (p = 0.62).
More Details:
Free fatty acids are associated with insulin resistance but not coronary artery atherosclerosis in rheumatoid arthritis |
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