26 The role of properdin in murine atherosclerosis
T Steiner, L Francescut, C Stover... - Heart, 2011 - Background Atherosclerosis in humans and mice has inflammatory, immune and metabolic components. Mice lacking low-density lipoprotein receptor (LDLR (−/−)) may be protected from atherogenesis by some components of the complement system. The serum ...
Results On LFD, there were no differences in body weight, atherosclerotic burden in aortae and lipid profiles between genotypes (LDLR(−/−)P-KO vs LDLR(−/−)P-WT) or genders. This was not the case in mice fed the HFD. On HFD, % lesion coverage in the aorta was greater in female LDLR(−/−)P-KO mice compared with males (5.06±0.71 % (f) vs 1.44±0.16 % (m), p>
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26 The role of properdin in murine atherosclerosis |
