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... -Transcriptional Silencing of SCN1B and SCN2B Genes Modulates Late Sodium Current in Cardiac Myocytes from Normal Dogs and Dogs with Chronic Heart Failure

S Mishra, NA Undrovinas... - American Journal of ..., 2011 - Am Physiological Soc The emerging paradigm for Na + current in heart failure (HF) is that its transient component (I Na T ) responsible for the action potential (AP) upstroke is decreased, whereas the late component (I Na L ) involved in AP plateau is augmented. Here we tested whether Na v β 1 and Na v ...

Association of Serum Phosphate Levels With Aortic Valve Sclerosis and Annular Calcification: The Cardiovascular Health Study

JP Linefsky, KD O'Brien, R Katz... - Journal of the ..., 2011 - Am Coll Cardio Found Methods: We measured serum levels of phosphate, calcium, parathyroid hormone, and 25-hydroxyvitamin D in 1,938 Cardiovascular Health Study participants who were free of clinical cardiovascular disease and who underwent echocardiographic measurements of aortic valve sclerosis ( ...

E Integrative genomics approaches identify new genes controlling heart rate

JS Ware, H Dobrzynski, M Pravanec, PJ Muckett... - Heart, 2011 - Abstract Introduction Heart rate (HR) is a fundamental measure of cardiac function, and is of prognostic and therapeutic significance. We applied genetic and genomic approaches to identify new loci and genes controlling HR in a rat model that has previously been used to ...

Does the combination of a renin inhibitor with a statin have potential for improved inhibition of atherosclerosis?

PWF Hadoke - Journal of Hypertension, 2012 - Correspondence to Patrick WF Hadoke, Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UKTel:+ 44 131 242 6770; fax:+ 44 131 242 6779; e-mail: phadoke@ staffmail. ed. ac. uk [PDF]

Relationships between changes in patient-reported health status and functional capacity in outpatients with heart failure

KE Flynn, L Lin, GW Moe, JG Howlett, LJ Fine... - American Heart ..., 2012 - Elsevier BACKGROUND: Heart failure trials use a variety of measures of functional capacity and quality of life. Lack of formal assessments of the relationships between changes in multiple aspects of patient-reported health status and measures of functional capacity over time ... [HTML]
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