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Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: Effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis

SM Soyal, A Sandhofer, P Hahne, H Oberkofler... - Atherosclerosis, 2011 - Elsevier OBJECTIVE: HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other. We studied associations of CETP-Taq1B and-514C> T-LIPC polymorphisms with hepatic m RNA levels, and their combined effects on ...

Voluntary wheel running increases bile acid as well as cholesterol excretion and decreases atherosclerosis in hypercholesterolemic mice

M Meissner, E Lombardo, R Havinga, UJF Tietge... - Atherosclerosis, 2011 - Elsevier OBJECTIVE: Regular physical activity decreases the risk for atherosclerosis but underlying mechanisms are not fully understood. We questioned whether voluntary wheel running provokes specific modulations in cholesterol turnover that translate into a decreased ...

Randomized trial of stents versus bypass surgery for left main coronary artery disease

SJ Park, YH Kim, DW Park, SC Yun... - ... England Journal of ..., 2011 - Mass Medical Soc Background Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main coronary artery stenosis, although coronary-artery bypass grafting (CABG) has been considered to be the treatment of choice.

Myocarditis: a defect in central immune tolerance?

TC Metzger... - The Journal of clinical investigation, 2011 - Myocarditis, or inflammation of the heart, is a potentially devastating disease that can result from both viral infection and autoimmune attack of self antigens in the heart. In the current issue of the JCI, Lv and colleagues use a genetically susceptible mouse model to show ...

Comparison of the Global Statistical Test and Composite Outcome for Secondary Analyses of Multiple Coronary Heart Disease Outcomes

S Baraniuk, R Seay, AK Sinha... - Progress in Cardiovascular ..., 2012 - Elsevier Multiple outcomes (or multiple endpoints), such as mortality and recurrent myocardial infarction, are increasingly common in clinical trials and are often of interest in secondary analyses. Traditionally, a clinical trial protocol is built around a single event as its primary ...
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