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Global DNA Methylation and Risk of Subclinical Atherosclerosis in Young Adults: The Pathological Determinants of Atherosclerosis in Youth (PDAY) Study

J Bressler, LC Shimmin, E Boerwinkle... - Atherosclerosis, 2011 - Elsevier Global DNA methylation was not associated with disease risk in the study population considered as a whole using conditional logistic regression models to analyze matched pairs. Since the estimation of the risk of atherosclerosis associated with inter-individual variation in DNA ...

As Serious as a Heart Attack

WE Mashman - JACC Interventions, 2011 - Advances in the treatment of acute coronary syndromes (ACS) have been blazing fast, and it seems like the general public has lost its mind. The unintended consequence of the successes of our field has been a growing public misperception of the gravity of coronary ...

Correlation Between Homocysteine Levels and Risk Factors for Cardiovascular Disease: Age, Gender, and BMI Dependency among Jackson Heart Study Participants

OR Henry - 2012 - Background. Elevated plasma homocysteine is a well established risk factor for cardiovascular disease (CVD). Homocysteine levels are strongly influenced by dietary components, particularly folic acid and vitamin B12 intake. While much data exists ...

Subclinical Coronary Atherosclerosis Predicts Cardiovascular Risk in Different Stages of Hypertension

R Erbel, N Lehmann, S Mhlenkamp... - ..., 2012 - Am Heart Assoc Abstract Prehypertension is a frequent condition and has been demonstrated to increase cardiovascular risk. However, the association with coronary atherosclerosis as part of target organ damage is not well understood. We investigated the cross-sectional relationship ...

Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1

X Yang, Q Li, X Lin, Y Ma, X Yue, Z Tao... - The FASEB Journal, 2012 - FASEBAbstract We have previously found that in failing human hearts, Rho-associated coiled-coil protein kinase 1 (ROCK1) is processed by caspase-3 into an active isoform, ROCKΔ1. The purpose of the current investigation was to elucidate the pathological consequences of ...
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