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Accelerated subclinical coronary atherosclerosis in patients with familial hypercholesterolemia

LA Neefjes, GJ ten Kate, R Alexia, K Nieman... - Atherosclerosis, 2011 - Elsevier A total of 140 asymptomatic statin treated FH patients (90 men; mean age 52 8years) underwent CT calcium scoring (Agatston) and CTCA using a Dual Source CT scanner with a clinical follow-up of 29 8 months. The extent, severity (obstructive or non-obstructive plaque ...

Primary Prevention of Coronary Heart Disease With Statins

JS Schwartz - Circulation, 2011 - Am Heart Assoc In the current issue of Circulation, Lazar et al report the results of their modeling of the cost-effectiveness of alternative statin treatment strategies for primary prevention using low-cost, lower-potency generic statins. 1 Lazar's study informs clinical decisions and practice guidelines about ...

Animal models of atherosclerosis.

JJ Fuster, AI Castillo, C Zaragoza... - Progress in molecular ..., 2012 - Cardiovascular disease is currently the predominant cause of mortality worldwide and its incidence is expected to increase significantly during the next decades owing to the unhealthy effects of modern lifestyle habits (eg, obesity and lack of physical exercise). ...

Studies of aging, metabolism and the age-dependent disease atherosclerosis in mouse mutants with altered mitochondrial function

B Hughes - 2012 - Abstract: Mutational disruption of the genes clk-1 and isp-1, the products of which are involved in mitochondrial oxidative phosphorylation, has been shown to extend lifespan in the nematode worm Caenorhabditis elegans. Here, we describe efforts to characterize the ...

Assessment of coronary artery disease wall thickening using phase-sensitive black-blood MRI: initial experience for the evaluation of coronary artery disease

K Abd-Elmoniem, RI Pettigrew... - Journal of Cardiovascular ..., 2012 - Background Coronary arterial wall imaging is a promising non-invasive tool for quantitative assessment of arterial remodeling. Conventional techniques mandate imaging during cardiac rest period as well as nulling the blood signal inside the arterial lumen in order to ...
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