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A Common Variant in the Beta-2 Adrenergic Receptor and Risk of Sudden Cardiac Death

MC Gavin, C Newton-Cheh, JM Gaziano, NR Cook... - Heart Rhythm, 2011 - Elsevier Homozygosity for the Gln27 allele conferred a non-significant elevation of the age-adjusted odds ratio (OR=1.22; 95% CI, 0.98-1.53; P=0.08) for SCD, which became marginally significant after controlling for multiple cardiac risk factors (OR=1.30, 95% CI: 1.01-1.67; P=0.046). In ...

Arrhythmia Formation in Subclinical (“Silent”) Long QT Syndrome Requires Multiple Insults: Quantitative Mechanistic Study Using the KCNQ1 Mutation Q357R as ...

T O'Hara... - Heart Rhythm, 2011 - Elsevier Background In subclinical, or silentlong QT syndrome (LQTS), the QT interval is normal under basal conditions. The hypothesis thatinsults to the repolarization reserve may cause arrhythmias insilent mutation carriers, but not in non-carriers, has been proposed as a ...

Outcomes of Drug-Eluting Stents for Protected Left Main Coronary Artery Disease (from the Multicenter, United States DEScover Registry)

J Leitner, HA Vlachos, F Selzer, SM Jamal... - The American Journal of ..., 2011 - Elsevier Methods The DEScover is a prospective multicenter observational study designed to characterize patients with PCI from a broad sampling of hospitals and practices. Details of the study design have been previously described. 8 In brief, from January through June ...

White Matter Protection in Congenital Heart Surgery

N Ishibashi, J Scafidi, A Murata, L Korotcova... - Circulation, 2012 - Am Heart Assoc BackgroundNeurodevelopmental delays in motor skills and white matter (WM) injury have been documented in congenital heart disease (CHD) and after pediatric cardiac surgery. The lack of a suitable animal model has hampered our understanding of the cellular ...

Regenerative Therapies for Improving Myocardial Perfusion in Patients with Cardiovascular Disease: Failure to Meet Expectations but Optimism for the Future.

FW Sellke, AD Lassaletta, MP Robich... - Current vascular ..., 2012 - Cardiovascular disease continues to be a major cause of death in the Western world and has been extending into areas previously seemingly immune to its effects. Catheter-based interventions and coronary artery bypass surgery have markedly improved cardiovascular ... [PDF]
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