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NASH and atherosclerosis are two aspects of a shared disease: central role for macrophages

V Bieghs, PCN Rensen, MH Hofker... - Atherosclerosis, 2011 - Elsevier Macrophage infiltration into the atherosclerotic lesion is known to play a central role in the initiation of atherosclerosis. In contrast, the role of macrophages during the etiology of non-alcoholic steatohepatitis (NASH) has been considered to be merely a late consequence of steatosis. However, ...

Circulating omentin is associated with coronary artery disease in men

R Shibata, N Ouchi, R Kikuchi, R Takahashi... - Atherosclerosis, 2011 - Elsevier Abstract Objective Obesity is closely associated with an increased risk for cardiovascular morbidity and mortality. Omentin is a fat-derived secreted factor that is downregulated in obesity. We investigated whether circulating omentin associates with the prevalence of ...

Autonomic dysfunction and cardiac arrhythmia in patients with obstructive and central sleep apnea].

U Koehler, C Reinke, E Sibai... - Deutsche ..., 2011 - Obstructive sleep apnea and central sleep apnea with Cheyne-Stokes respiration are associated with an increased risk of cardiac arrhythmia. Apnea-associated arrhythmia may contribute to sudden cardiac death and premature mortality in those patients. Both forms ...

Natural Antibodies and Atherosclerosis

D Tsiantoulas... - Inflammation and Atherosclerosis, 2012 - Springer The view of atherosclerosis as an inflammatory disease has been strongly supported by studies demonstrating the ability of both the innate and adaptive immune system to modulate its initiation and progression. Different explanations exist as to why the immune ...

The risk of elevated resting heart rate on the development of type 2 diabetes in patients with clinically manifest vascular diseases

RH Bemelmans, AM Wassink, Y Van der Graaf... - European Journal of ..., 2012 - EFESObjective. Sympathetic nerve activation is causally related to insulin resistance as both a cause and a consequence. Resting heart rate (RHR) reflects sympathetic nerve activity. We investigated the influence of RHR on the incidence of type 2 diabetes mellitus (T2DM) in ...
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